Season 6: Episode 5: Lois Kills Stewie
Presumed dead, Lois returns to name Stewie as the person who tried to kill her. On the look out for Stewie, Joe leads a manhunt around Quahog. Determined to take over the world again, Stewie does whatever he can to become supreme ruler of the world. Desperate to stop Stewie, Lois realizes what she must do.